IndraLab

Statements

CD44 binds CD274. 21 / 21
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"This review is devoted to describing the features of co-expression and the mechanisms of interaction between CD44 and PD-L1."
38010641
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"In summary, these results demonstrate that CD44 was associated with PD-L1 and infiltration of immune cells, and was a negative prognostic factor for predicting worsened OS in lung adenocarcinoma."
33372595
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"The nuclear PD-L1 (nPD-L1) interacts with CD44, leading to nPD-L1 complex formation, activation of the RASGEF1A promoter, initiation of the Ras pathway, and contributing to Osimertinib resistance."
39773749
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"Our data are consistent with the established mechanism whereby PD-L1 expression is initiated through CD44 binding to PD-L1 regulatory regions."
41597220
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"Altogether, our findings suggest that PD-L1 interacts with CD44, translocates into the nucleus facilitated by eIF5B and Importin-β1, and activates the RASGEF1A promoter through the transcription factor function of CD44."
39773749
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"Importantly, we found that PD-L1 could interacted with CD44 and bring it into the nucleus (we designated them as the nPD-L1 complex) and functioned as a potential transcription factor."
39773749
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"Thus, this positive association between CD44 and PD-L1 might provide the rationale for investigating the effect of monoclonal PD-L1/PD-1 antibodies administration on the CD44 expression and stemness of TNBC cells in affected patients.The current systematic review has several strengths."
34434894
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"We applied the GEPIA2.0 database to analyze the association of CD44 with osteosarcoma immune checkpoint-related proteins CD274, CD47, CTLA 4, and CD276 and found that CD44 has a positive relationship with them ( xref C)."
37287706
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"Splenic naive CD44 low CD8 + T cells isolated from WT and Cbl-b -/- mice were stimulated with anti-CD3 and anti-CD28 abs in the presence of plate bound PD-L1 Ig or control Ig."
28184224
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"Consequently, our state-of-the-art 3D models can be utilized to assess the biological activity of novel multi-target molecules designed to interact with CD44 and PD-L1, with the objective of eradicating aggressive CD44 + populations and augmenting the efficacy of immune checkpoint inhibitors."
41597220
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"A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma."
39773749
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"The interaction between CD44 and PD-L1 might inspire us to combine therapy to treat gliomas, such as blocking CD44 and other immune checkpoints.RUNX1 has been identified as a critical transcription factor regulating multiple biological processes of cancer (49)."
36776876
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"This review is devoted to describing the features of co-expression and the mechanisms of interaction between CD44 and PD-L1."
38010641
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"We found a positive association between YAP1 and VIM, CD44, and PD-L1, while YAP1 negatively correlated with CDH1 (Figure 1D)."
| PMC
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"A study found that in TNBC and NSCLC, the cell surface adhesion receptor CD44 was a critical positive regulator of PD-L1; CD44 could bind to the regulatory region of PD-L1, which contains the CD44-ICD binding site and activates PD-L1 transcription through its ICD; the activated PD-L1 could promote tumor cell proliferation independent of T cell response ( xref )."
36466997
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"Positive association between CD44 and PD-L1 were found in lung adenocarcinoma patients."
33372595
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"3.7 Nuclear eIF5B/PD-L1/CD44 complex enhances the transcription of RASGEF1A, which is responsive for Ras signaling activation and Osimertinib resistance."
39773749
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"Furthermore, a positive association between the stem-marker CD44 and PD-L1 was reported in NSCLC (53)."
38765006
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"In this study, our docking simulations of HNC0014 revealed strong interactions between HNC0014 and c-Met, STAT3, PD-L1, and CD44."
33327484
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"Our results indicated that ALDH1 was inversely correlated with PD-L1 by IHC and mRNA data and that CD44 was positively associated with PD-L1 in the mRNA database for lung adenocarcinoma."
33036771
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"The interaction between CD44 and PD-L1 might inspire us to combine therapy to treat gliomas, such as blocking CD44 and other immune checkpoints."
36776876