IndraLab

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USP9X deubiquitinates IQCB1. 4 / 4
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"In fact, in growth-arrested conditions, USP9X is recruited at the centrosome, deubiquitylates NPHP5 and prevents its degradation and cilium disassembly (Das et al., 2017)."
35646931
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"Only wild type USP9X could robustly deubiquitinate NPHP5 (XREF_FIG)."
28498859
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"Because USP9X deubiquitinates NPHP5 (XREF_FIG), we hypothesize that NPHP5 is prone to ubiquitination when its association with USP9X is compromised in G2/M."
28498859
ubibrowser
"<span class="match term1">NPHP5</span> directly binds to a deubiquitinating enzyme <span class="match term0">USP9X</span>/FAM and two E3 ubiquitin ligases BBS11/TRIM32 and MARCH7/axotrophin. <span class="match term1">NPHP5</span> undergoes K63 ubiquitination in a cell cycle dependent manner and K48/K63 ubiquitination upon <span class="match term0">USP9X</span> depletion or inhibition"
28498859