IndraLab

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CYLD inhibits necroptotic process. 14 / 14
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"Later, Green et al. hypothesized that cFLIP L /Caspase 8 heterodimer cleaves and inactivates the signaling molecules leading to necroptosis, such as RIPK1, RIPK3, and CYLD, thereby inhibiting necropto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In apoptotic signaling, caspase-8 may cleave de-ubiquitinase CYLD, RIP1 and RIP3, blocking initiation of necroptosis."
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"Caspase-8 also targets the deubquitinase CYLD preventing RIPK1 initiation of necroptosis [XREF_BIBR, XREF_BIBR]."
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"Which substrates are cleaved preferentially by the caspase-8/cFLIP heterodimer to prevent necroptosis, and the molecular mechanism that alters caspase-8 specificity when forming a heterodimer with cFLIP are questions that need assessment.Several known caspase-8 substrates have roles in necroptosis: caspase-8 itself, cFLIP , RIPK1, RIPK3, and the RIPK1-deubiquitylating enzyme cylindromatosis (CYLD) [100,104,105,106]."
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"Furthermore, KIAA1191 high expression suppressed the proliferation and migration of MM cells; upregulated the expression of RIP1, RIP3, and CYLD, and restored the TNF-α/z-VAD-induced necroptosis."
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"Surprisingly, inhibition of both TBK1 and Caspase-8 activation significantly increases (CXCL4 + TLR8)-induced necroptosis, which could be suppressed by jointly inhibition of MLKL, RIPK1 or CYLD, respectively."
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"Accordingly, knockdown, deletion, or inactivation of CYLD renders cells less sensitive to TNF-induced necroptosis [88–91]."
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"Since CYLD is less efficient at deubiquitinating RIP1, this results in a much lower overall rate of RIP1 deubiquitination and a significant increase in TTD, i.e., CYLD, counterintuitively, inhibits necroptosis in this mode."
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"Hitomi et al. (9) showed that increased CYLD expression reduces necroptosis in human T lymphocyte cells."
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"Caspase-8 also targets the deubiquitinase cylindromatosis CYLD which further prevents RIPK1 initiation of necroptosis [119]."
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"Recently, CYLD was shown to negatively regulate necroptosis induced by oxygen-glucose-deprivation (OGD) in primary cortical neurons."
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"Cleavage of CYLD by caspase-8 was proposed to suppress necroptosis, but it was inhibited by the viral serpin CrmA [51] ."
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"Thus, in the case of KP35 infection, induction of necroptosis is not due to increased CYLD, but rather the previously observed inhibition of necroptosis by CYLD was not detected."
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"The inhibition of cIAP and activation of CYLD could also promote necroptosis XREF_BIBR, XREF_BIBR."
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