IndraLab

Statements

CYLD inhibits necroptotic process. 6 / 6
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"Furthermore, KIAA1191 high expression suppressed the proliferation and migration of MM cells; upregulated the expression of RIP1, RIP3, and CYLD, and restored the TNF-α/z-VAD-induced necroptosis."
34989828
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"Caspase-8 also targets the deubquitinase CYLD preventing RIPK1 initiation of necroptosis [XREF_BIBR, XREF_BIBR]."
27710879
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"Recently, CYLD was shown to negatively regulate necroptosis induced by oxygen-glucose-deprivation (OGD) in primary cortical neurons."
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"The inhibition of cIAP and activation of CYLD could also promote necroptosis XREF_BIBR, XREF_BIBR."
23835476
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"In apoptotic signaling, caspase-8 may cleave de-ubiquitinase CYLD, RIP1 and RIP3, blocking initiation of necroptosis."
22658960
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"Thus, in the case of KP35 infection, induction of necroptosis is not due to increased CYLD, but rather the previously observed inhibition of necroptosis by CYLD was not detected."
28125817