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KCNK2 inhibits calcium(2+). 6 / 6
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"In combination with the results of membrane potential experiments, reduced activity of TREK1 channels causes membrane depolarization and subsequent decrease in [Ca 2+ ] cyt in HSCs.Activated HSCs spec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Low doses of mini-spadin evoked TREK-1, and the activation of TREK-1 in neurons hyperpolarized synaptic terminals, decreased Ca influx and glutamate release, and produced postsynaptic hyperpolarization."
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"Inhibition of TREK-1 by SPA induced a decrease of the resting membrane potential (DeltaV m ~ 12mV) and increased the cytosolic calcium concentration."
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"TASK2 and TREK1 blockade led to a decreased K + outward current and a decrease of ACh dependent Ca 2+ influx in C2C12 cells as potential underlying mechanisms."
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"This suggests that TREK-1 inhibition may accelerate PKC-dependent pathways, influencing both calcium dynamics and cellular differentiation processes (Fig. 4A–C)."
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"These findings collectively indicate the existence of a positive feedback loop, whereby TREK-1 inhibition-induced depolarization results in increased intracellular calcium levels."
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