IndraLab

Statements

KCNMA1 activates CASP1. 10 / 10
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"Thus, sublytic SLO can promote HMGB1 release and Casp1 activation in a NLRP3 inflammasome dependent manner."
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"TLR signaling is required for caspase-1 activation induced by SLO and LPS or synthetic lipopeptide but not S. pyogenes infection."
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"However, SLO could promote caspase-1 activation by mediating internalization of microbial molecules distinct of TLR ligands."
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"We tested whether sublytic SLO challenge promotes inflammasome activation by comparing Casp1 activation and HMGB1 secretion in WT, NLRP3 -/-, and Casp1 -/- BMDM treated with sublytic or lytic doses of SLO."
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"We found that in WT BMDM, sublytic SLO doses activated Casp1 and depleted HMGB1 from cell lysates, resulting in extracellular HMGB1 release."
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"Consistently, activation of caspase-1 induced by LPS or synthetic lipopeptide in the presence of SLO was impaired in macrophages deficient in Myd88 and Trif (XREF_FIG)."
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"The addition of recombinant SLO to cells exposed to bacterial molecules such as muramyl dipeptide or flagellin can induce the activation of caspase-1."
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"TLR signaling is required for caspase-1 activation induced by SLO and LPS or synthetic lipopeptide but not S. pyogenes infection."
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"Because activation of caspase-1 induced by LPS or lipopeptide and SLO requires TLR signaling, the results suggest that MyD88 and Trif independent activation of the Nlrp3 inflammasome in response to S. pyogenes infection can not be explained by SLO mediated internalization of TLR ligands."
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"Although not required, additional stimulation of bacterial RNA transfected cells with the classical second signals ATP or pore forming bacterial toxins nigericin and SLO enhanced and accelerated caspase-1 activation and release of IL-1beta (XREF_FIG; note decrease in pro-IL-1beta levels due to cleavage)."
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