IndraLab

Statements

ATM phosphorylates USP28. 13 / 15
1 | 5 8 1
sparser
"In response to DNA damage, phosphorylation of the deubiquitinase USP28 by DDR kinases, ATM, and ATR leads to deubiquitination of either GATA4 or its associated factor [ xref ]."
33557090
reach
"In response to 5 '-AZA, UCK1 and USP28 are phosphorylated by ATM, instigating entirely different effects on the protein protein interaction."
31938050
reach
"In response to DNA damage, phosphorylation of the deubiquitinase USP28 by DDR kinases, ATM, and ATR leads to deubiquitination of either GATA4 or its associated factor [XREF_BIBR]."
33557090
sparser
"Once all the three conservative SQ sites (S67, S495, and S714), in USP28, were mutated to alanine, the pS/TQ antibody completely could not recognize the immunoprecipitated Flag-USP28-3S/A (Figure xref D), suggesting that in response to 5'-AZA-induced stress, ATM phosphorylates USP28 at all these three sites."
31938050
sparser
"It cannot be excluded the possibility that kinases other than ATM could phosphorylate USP28 under DNA damage stress."
| PMC
reach
"The downstream ATM kinase CHK2 could be a potential candidate to phosphorylates USP28 following DNA damage."
| PMC
sparser
"USP28 is required for p53 and p21 accumulation following p53 activation ( xref E–G) and is phosphorylated on at least three sites by ATM in response to IR ( xref )."
29089421
sparser
"We next asked whether ATM or ATR phosphorylates USP28 upon CPPD treatment."
34611298
reach
"Once all the three conservative SQ sites (S67, S495, and S714), in USP28, were mutated to alanine, the pS/TQ antibody completely could not recognize the immunoprecipitated Flag-USP28-3S/A, suggesting that in response to 5 '-AZA-induced stress, ATM phosphorylates USP28 at all these three sites."
31938050
sparser
"These novel findings establish a direct connection between the ubiquitination of UCK1 by KLHL2 and phosphorylation of USP28 and UCK1 by ATM, which are involved in mediating drug resistance against 5'-AZA in AML patients."
31938050
sparser
"During DNA damage, the catalytic activity of USP28 is increased due to the phosphorylation of USP28 by the kinase ATM [ xref ]."
38498222
reach
"USP28 is also phosphorylated by ATR and ATM and is involved in the response to DNA damage by virtue of its ability to deubiquitinate and stabilize FBW7 (see below), the ubiquitin ligase involved in the degradation of the myc transcription factor."
19489724
sparser
"In response to 5'-AZA, UCK1 and USP28 are phosphorylated by ATM, instigating entirely different effects on the protein-protein interaction."
31938050