IndraLab

Statements

USP8 deubiquitinates CTNNB1. 8 / 8
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"USP8 deubiquitylates beta-catenin."
37311739
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"Conversely, ectopic expression of USP8-WT, but not USP8-C786A, significantly inhibited the ubiquitylation of β-catenin in cells (Fig. 4A, B)."
37311739
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"Since USP8 deubiquitinates and stabilizes β-catenin in HCC cells, we then tested whether USP8 regulates these functions via modulating β-catenin."
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"Importantly, the inhibition of β-catenin and Twist1 effectively suppresses the stemness induced by USP4.Previous studies have shown that USP8 and USP20 can deubiquitinate β-catenin, while DUB3 and USP51 target Twist1 [50–53]."
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"Besides, USP8 decreased β-catenin polyubiquitination and promotes OGT protein stabilization."
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"Second, USP8 decreased β-catenin polyubiquitination and promotes β-catenin protein stabilization in a manner that depending on its DUB activity."
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"Ectopic expression of USP8-WT, but not USP8 , significantly decreased the ubiquitylation of β-catenin."
37311739
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"Mechanistically, USP8 deubiquitinates and stabilizes β-catenin in a catalytic activity-dependent manner."
37311739