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JOSD1 activates apoptotic process. 4 / 4
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"We found that ATXN3 inhibited apoptosis, while JOSD1 and JOSD2 promoted apoptosis, JOSD2 inhibited DNA damage response, JOSD1 and JOSD2 promoted EMT, and JOSD2 suppressed RTK and androgen pathways.Moreover, we used the cBioPortal database to explore the co-expression (Table 3) and mutual exclusion (Table 4) between individual members of the MJDs family."
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"JOSD1 depletion led to severe apoptosis in gynaecological cancer cells both in vivo and in vitro."
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"Since the absence of JOSD1 caused significant enhancement of apoptosis, we proceeded to address how JOSD1 confers protection against proteotoxic stress."
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"In contrast to the depletion of JOSD1, we observed that expression of JOSD1 caused a noticeable reduction in cellular apoptosis as evidenced by decreased expression of CC3 and cleaved PARP (Fig. 2A) and in the number of dead cells (Fig. 2B)."
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