IndraLab

Statements

USP19 increases the amount of MMP9. 5 / 5
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"We first found overexpressing USP19 increased MMP2 and MMP9 protein levels."
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"Furthermore, they showed that increased USP19 (TM isoform) levels enhanced MMP2/MMP9 protein expression and enzyme activity, and that genetic alteration of USP19 levels affected tumorigenesis using in vivo models."
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"Our study suggests that USP19 promoted tumor progression by inducing MMP2 and MMP9 expression and related enzyme activity."
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"Moreover, the ability of USP19 to enhance the migratory and invasive abilities of GC cells by increasing MMP2 and MMP9 expression was evaluated using gelatin zymography."
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"Our results first indicated that USP19 enhanced MMP2 and MMP9 protein expression as well as enzyme activity."
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