IndraLab

Statements

USP8 increases the amount of MUC12. 5 / 5
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"USP8 upregulates MUC12 expression through deubiquitination."
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"Moreover, the rescue experiments also suggested that in the A498 cell line with knockdown of piR-1742, overexpression of USP8 rescued the expression of MUC12."
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"However, knockdown of USP8 in the piR-1742-overexpressing 786-O cell line reduced MUC12 expression (Fig. 6j)."
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"Notably, USP8 knockdown suppressed MUC12 expression, and the promoting effects of MUC12 on angiogenesis were blocked by silencing of piR-1742."
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"Overexpression of USP8 increased the deubiquitination level of MUC12, leading to an increase in the MUC12 protein level."
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