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Statements

USP4 phosphorylates USP4. 3 / 3
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"They further showed that USP4 could interact with Akt at endogenous level, and phosphorylate USP4 in vitro and in vivo."
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"However, upon growth factor stimulation, AKT will phosphorylate both TSC2 and the deubiquitinase ubiquitin specific peptidase 4 (USP4), resulting in the release of Rheb from the inhibitory effect of the TSC complex [44]."
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"Direct association of USP4 with TβRI at the plasma membrane and USP4-mediated TβRI deubiquitylation are enhanced in response to Akt activation and Akt-mediated USP4 phosphorylation, and directly oppos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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