IndraLab

Statements

USP8 activates RNF41. 4 / 9
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"We tested the importance of USP8 to Clec16a-mediated Nrdp1 stability by both gain- and loss-of-function approaches."
29180353
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"Our results indicate that Nrdp1 is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 activity by mediating its stabilization."
15314180
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"Since Nrdp1 targets USP8 for ubiquitylation, we speculated that overexpression of Nrdp1 could enhance protein ubiquitylation and USP8 degradation in PC12 cells."
28979191
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"USP8 markedly enhanced the stability of Nrdp1, and a point mutant that disrupts USP8 catalytic activity destabilized endogenous Nrdp1."
15314180