IndraLab

Statements

USP8 activates RNF41. 7 / 12
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"Since Nrdp1 targets USP8 for ubiquitylation, we speculated that overexpression of Nrdp1 could enhance protein ubiquitylation and USP8 degradation in PC12 cells."
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"Thus, LPS increased MyD88-dependent signaling pathway activation, which could be inhibited by USP8 treatment, indicating that USP8 may act on microglia by inhibiting TLR4 to attenuate LPS-induced neur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP8 promotes the stabilization of E3 ubiquitin ligase Nrdp1 ( Wu et al., 2004 ), and Nrdp1 regulates NF-κB and type I IFNs by targeting MYD88 and TBK1 ( Wang et al., 2009 )."
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"We tested the importance of USP8 to Clec16a-mediated Nrdp1 stability by both gain- and loss-of-function approaches."
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"Nrdp1 is a specific target for USP8 deubiquitinating enzyme, and USP8 could augment Nrdp1 activity by mediating its stabilization ( Wu et al., 2004 )."
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"USP8 markedly enhanced the stability of Nrdp1, and a point mutant that disrupts USP8 catalytic activity destabilized endogenous Nrdp1."
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"Our results indicate that Nrdp1 is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 activity by mediating its stabilization."
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