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BRCC3 increases the amount of IL1B. 3 / 3
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"A recent study showed that BRCC3 could regulate the activation of NLRP3 inflammasome by deubiquitination, and the inhibitor of BRCC3 could inhibit the activation of NLRP3 inflammasome and the secretio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Experiments showed that siRNA BRCC3 significantly downregulated the protein levels of NLRP6, cleavated caspase-1 and IL-1β, reduced neutrophil infiltration, and improved neurological dysfunction in MCAO mice [48]."
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"In addition, downregulation of BRCC3 neither by inhibitor nor shRNA lentiviruses blocked the secretion of IL-1β induced by MPP + -treatment in primary cortical neurons ( Fig. 4 C)."
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