IndraLab

Statements

CACNA1C activates cell population proliferation. 5 / 5
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"Conditional knockdown of Cav1.2 in astrocytes can block calcium influx by 80% and reduce LPS-induced activation and proliferation of astrocytes [60]."
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"However, in proliferating A7r5, Ca 2+ entry through CaV1.2 promotes proliferation rather than differentiation [ 64 ], suggesting that CaV1.2 is active prior to electrical coupling."
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"Similarly, under basal conditions in vivo, Cacna1c gene deletion in type-1 cells decreased type-1 cell proliferation and reduced the neuronal fate-choice decision of newly born cells, resulting in reduced net hippocampal neurogenesis."
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"Interestingly, Ca V 1.2 and Ca V 1.3 blockade reduces the number of cells in anaphase and telophase, therefore decreasing cell proliferation [ 64 ]."
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"CCK8, colony-forming, flow cytometry, and Western blot assays showed that knockdown of CACNA1C inhibited the proliferation of LN229 and U251 cells (Supplementary Fig. 3a–d)."
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