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USP25 inhibits inflammatory response. 12 / 12
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"Indeed, deletion of USP25 significantly increased the production of TNF-α, IL-1β, and IL-6 in both SV40 cells and BMDMs upon stimulation with AGEs in vitro ( Fig. 7 A-F), confirming the in vivo findin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been reported that the expression of IL-17 in the serum and tissues of IgG4-RD patients is increased and that USP25 negatively regulates the signaling and inflammation induced by IL-17 ."
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"Additionally, Zhong et al. reported that overexpression of USP25 inhibits IL-17-triggered signaling and inflammation by interacting with TRAF5 and TRAF6 in helper lymphocyte-mediated immune responses [33]."
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"For example, USP25 inhibits experimental autoimmune encephalomyelitis by inhibiting IL‐17‐induced signaling and inflammation."
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"IL-17-mediated inflammation is also attenuated by USP25 through TRAF5 and TRAF6 deubiquitination [66]."
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"Ubiquitin specific peptidase 25 alleviates acute lung injury and suppresses the inflammatory response in lung epithelial cells."
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"In addition, USP25 significantly increases the abundance of BARD1 protein and prevents HDM-induced DNA damage and inflammation [90] ."
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"This study found that USP25 is involved in regulating the ubiquitination of P62, promoting the degradation of TAK1 in cardiomyocytes through the autophagy-lysosome pathway, improving TAK1/MAPK-mediated myocardial inflammation, and finally alleviating obesity-induced ventricular remodeling and cardiac insufficiency.TRANSLATIONAL OUTLOOK: Our data indicated that USP25 can inhibit myocardial inflammation, which is an important mechanism for the development of OCM, and USP25 was found to function through the TAK1/MAPK axis."
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"We further found that USP25 inhibited renal inflammation in DKD by inhibiting inflammatory responses in glomerular mesangial cells and kidney-infiltrating macrophages via reducing K63 polyubiquitinati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, compared with USP25 +/+ T1DM mice, USP25 -/- T1DM mice had significantly higher levels of TNF-α, IL-6, CCL2, and CXCL10 in the kidney ( Fig. 3 A-D), indicating that USP25 inhibits kidne[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To identify the specific target mediating the suppression of inflammation by USP25, we performed immunoprecipitation–mass spectrometry (IP–MS) analysis using USP25-overexpressing 293T cells (Fig. 4A and Supplementary Table 1)."
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"These results indicate that USP25 restricts IL17 mediated pulmonary inflammation in vivo."
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