IndraLab

Statements

USP14 activates gate. 5 / 5
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"On the substrate-engaged pathway, ubiquitin-dependent activation of USP14 allosterically reprograms the conformational landscape of the AAA-ATPase motor and stimulates opening of the core particle gate 8-10 , enabling observation of a near-complete cycle of asymmetric ATP hydrolysis around the ATPase ring during processive substrate unfolding."
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"Conversely, USP14 might also activate proteolysis by degrading ubiquitin chains on target proteins and thereby enhance gate opening of the 20S proteasome."
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"In the presence of substrate, USP14 and Ubp6 enhance the ATPase rate, strengthen the interaction between the regulatory and the core particles and induce early gate opening."
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"In the presence of ubiquitylated substrates, USP14 stimulates the ATPase rate, tightens the RP–CP interface and induces early CP gate opening , as represented in states ED4USP14 and ED5USP14."
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"What defines whether Usp14 or Rpn11 wins this competition is another interesting question for future work.Second, prior work suggests that Usp14/Ubp6 stimulate the activity of the ATPase ring and open[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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