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Etomidate inhibits KCNH2. 4 / 4
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"XREF_FIG demonstrates that etomidate inhibited the tail current of the hERG in a concentration dependent manner, i.e., etomidate at concentrations of 10, 30, 100, 300, and 1000 muM reduced the tail current by 3.83 +/- 2.36%, 14.13 +/- 5.09%, 27.03 +/- 4.24%, 51.72 +/- 4.12% and 80.06 +/- 3.26% (n = 3), respectively."
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"The etomidate analogue, ET-26 HCl, inhibited the hERG current in a similar concentration dependent manner (XREF_FIG)."
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"In addition, the electrophysiology study indicated that ET-26 HCl and etomidate inhibited the hERG at a supra-therapeutic concentration."
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"In the in vitro Langendorff preparation, none of the cardiac parameters were abnormal, and the hERG recordings showed that ET-26 HCl and etomidate inhibited the tail current of the hERG in a concentration dependent manner with an IC 50 of 742.51 muM and 263.60 muM, respectively."
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