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Ceramide inhibits NFKBIA. 2 / 2

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"In addition, IL-1 or Cer increases activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) in a time and dose dependent manner, by reducing the levels of inhibitor of kappa-light-chain-enhancer of activated B cells IkappaBalpha and IkappaBbeta."

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"Rebamipide inhibited the ceramide induced degradation of IkappaB-alpha (a major cytoplasmic inhibitor of nuclear factor-kappaB), further supporting that rebamipide inhibits the activation of nuclear factor-kappaB."

11454909

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Ceramide inhibits NFKBIA. 2 / 2

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