IndraLab

Statements

CYLD increases the amount of RIGI. 2 / 2
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"Re-expression of CYLD in CYLD-deficient A549 cells blocked IAV-induced TBK1 and IRF3 phosphorylation and RIG-I expression (Fig. 7C), whereas re-expression of an uncleavable CYLD mutant (D215A) further reduced IAV-induced TBK1 and IRF3 phosphorylation and decreased the levels of IAV-induced RIG-I expression compared to those in CYLD-deficient cells transfected with the wild-type CYLD expression vector (Fig. 7D)."
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"CYLD silencing resulted in an increase of poly IC induced RIG-I and MDA5 protein levels and increased CCL5 and CXCL10 mRNA and protein expression, but unexpectedly decreased mRNA expressions of RIG-I and MDA5."
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