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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 inhibits RNF4. 2 / 7

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"In particular, we suggest that ataxin-3 is a functional antagonist of RNF4 during the signaling and repair of DSBs where it acts as a SUMO activated DUB on at least one of the identified RNF4 substrates : MDC1."

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"The RNF4 dependent clearance of MDC1 is antagonised by ATXN3, a DUB that is rapidly recruited to DSBs by SUMO [25]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...