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ATXN3 inhibits RNF4. 2 / 7

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"In particular, we suggest that ataxin-3 is a functional antagonist of RNF4 during the signaling and repair of DSBs where it acts as a SUMO activated DUB on at least one of the identified RNF4 substrates : MDC1."

28275011

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reach

"The RNF4 dependent clearance of MDC1 is antagonised by ATXN3, a DUB that is rapidly recruited to DSBs by SUMO [25]."

31769469

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IndraLab

Statements

ATXN3 inhibits RNF4. 2 / 7

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