IndraLab

Statements

TCR activates USP38. 4 / 4
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"USP38 is induced by TCR signaling and in turn promotes JunB stabilization to specifically regulate Th2 cell differentiation."
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"Considering that USP38 was induced by TCR signaling in T cells, but not induced in macrophages by the innate sensor triggers, we hypothesize that the observed USP38 expression in the infiltrated immune cells is likely due to its induction in T cells after OVA challenge.Apart from its essential role in TCR-induced JunB stability, we found that USP38 was dispensable for the cytokine (IL-4, IL-2, and IL-6)-induced signaling in T cells (Fig. S4, A–C)."
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"To explore this point, we pretreated cells with MG132 to block proteasome-mediated protein degradation and indeed found that MG132 restored the TCR-induced accumulation defect of JunB protein in USP38-deficient T cells (Fig. 8 D)."
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"Chen et al. reported that TCR stimulation (anti-CD3/CD28) promoted USP38 in allergic asthma."
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