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"For example, a marked decrease in c-fos levels was observed in the striatum of rats chronically treated with ethanol (Yang et al., 1998), and no increase in c-fos immunoreactivity was observed upon NMDA treatment of rats that have been chronically treated with vapor ethanol (Hardy et al., 1999)."
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"We have previously reported that rats selectively bred for alcohol preference show altered Arrb2 mRNA levels in several brain regions compared to their non preferring counterparts, and mice lacking the Arrb2 gene exhibit reduced alcohol induced locomotion and c-fos activation in the shell of nucleus accumbens in response to a low dose of alcohol, suggesting impaired alcohol reward."