IndraLab

Statements

PIK3C3 inhibits USP13. 3 / 3
| 3
reach
"It is interesting to note that the knock-down of VPS34 and BECLIN 1 also causes the degradation of USP10 and USP13, which indicates the existence of a regulatory feedback loop [XREF_BIBR]."
29186924
reach
"Interestingly, Vps34 acts as a regulator for autophagy, and Vps34 complexes down-regulate USP10 and USP13 by Beclin1, suggesting that they are downstream of autophagy activation ( Liu et al., 2011 )."
32470641
reach
"Using an imaging-based screen, Liu et al. (2011) recently identified a highly potent small molecule inhibitor of autophagy they named spautin-1 (specific and potent autophagy inhibitor 1), which promotes degradation of the Vps34 complexes via inhibiting ubiquitin-specific processing protease 10 (USP10) and USP13, two ubiquitin-specific peptidases that target the deubiquitination of Beclin1.2."
23943849