IndraLab

Statements

USP11 activates cell differentiation. 5 / 5
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"Roman Istomine et al. [114] found that USP11 potentiates TGF-β signaling in CD4 T cells to facilitate Foxp3 regulatory T and Th17 cell differentiation."
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"USP11 can stabilize the Msh homeobox 1 (MSX1) protein to upregulate the expression of osteogenic differentiation-related markers in human MSCs, consequently enhancing osteogenic differentiation (63)."
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"Interestingly, depletion of another BRCA1-interacting protein, BRCA2, results in defects of DNA repair but not that of differentiation in mammary cells (14), which suggests that not all intrinsic DNA repair defects induced by deficiency of BRCA1-interacting proteins promote or are associated with aberrant differentiation.In this study, we discovered that loss of USP11 reduced the expression of E-cadherin and induced DNA damage in MECs and that overexpression of USP11 promoted luminal differentiation, enhanced DNA damage repair, and suppressed tumorigenesis."
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"We show that Sox11 overexpression rescues the defects in RGC differentiation and neuronal migration caused by Usp11 deficiency, which supports the contribution of Sox11 stabilization to the effects of Usp11 on cortical development."
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"Additionally, differentiation studies revealed reduced calcification and alkaline phosphatase activity in USP11-depleted cells, while overexpression of USP11 enhanced the differentiation potential of hMSCs."
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