IndraLab

Statements


OTUB1 activates RNF128. 4 / 4
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"As Otub-1 is controlled by the Akt-mTOR pathway and is a negative regulator of the GRAIL function [XREF_BIBR, XREF_BIBR], this suggests that T. cruzi infection may disrupt the Akt-mTOR pathway resulting in Otub-1 downregulation, which in turn may induce GRAIL."

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"Moreover, the catalytic inactive C748S USP8 mutant made no difference on Otub1 mediated GRAIL stability."

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"This suggests that LAM may disrupt the Akt-mTOR pathway resulting in Otub-1 down-regulation, which in turn may induce GRAIL."

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"When mTOR is inhibited by rapamycin treatment during stimulation, although Otub1 mRNA is up-regulated, Otub1 protein is not expressed, allowing GRAIL to be maintained (XREF_FIG, third lane)."