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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OCA2 increases the amount of TNFAIP3. 1 / 1

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"During MeV infection, viral P protein activates the expression of the ubiquitin modifier TNFAIP3, which interacts with TRAF6 binding protein, TAX1BP1, forming a complex that acts as TRAF6 inhibitor by preventing E3 ligase TRAF6 polyubiquitination [XREF_BIBR], thus blocking the TLR4 mediated proinflammatory signaling [XREF_BIBR]."

| PMC

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...