IndraLab

Statements

OTUB1 inhibits TP53. 3 / 5
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"Our results demonstrate that cathepsin K inhibition enhances oxaliplatin-induced apoptosis by increasing OTUB1 phosphorylation via CK2 activation, thereby promoting p53 stabilization, and hence upregulating Bax."
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"This is particularly interesting when considering our observations that in prostate cancer cells, OTUB1 mediates the androgen inhibition of p53 through a mechanism that requires an intact OTUB1 catalytic motif and seems to be independent from MDM2 concentration changes."
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"Monoubiquitination of OTUB1 was found to suppress UbcH5 activity, thereby stabilizing p53 [85] ."
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