IndraLab

Statements

MARK2 inhibits KCNK18. 11 / 11
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"Since ca MARK2 inhibited TRESK but kd MARK2 did not evoke this effect, the kinase activity of MARK2 was indispensable for TRESK regulation."
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"The discrepancy, especially the cysteine to tyrosine substitution, raised the question whether human TRESK was also inhibited by MARK2."
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"Microinjection of constitutively active MARK2 protein acutely inhibited TRESK, and the enzyme activity of the coexpressed kinase was required for TRESK regulation."
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"MARK2 inhibits S264E mutant mouse TRESK."
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"TRESK Background K + Channel Is Inhibited by PAR-1 and MARK Microtubule Affinity Regulating Kinases in Xenopus Oocytes."
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"MARK1, MARK2 and MARK3 inhibit TRESK, but not all AMPK related kinases regulate the channel."
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"The three closely related members of the MARK family accelerated the recovery of K + current (XREF_FIG), indicating that MARK1, MARK2 and MARK3 inhibited TRESK channel."
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sparser
"MARK1, MARK2 and MARK3 inhibit TRESK, but not all AMPK-related kinases regulate the channel."
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"Thus MARK2 selectively inhibits TRESK activity via the S274/276/279 cluster, but does not affect the direct recruitment of 14-3-3 to the channel."
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sparser
"The discrepancy, especially the cysteine to tyrosine substitution, raised the question whether human TRESK was also inhibited by MARK2."
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sparser
"Thus coexpression of MARK2 inhibited TRESK under resting conditions, and dramatically accelerated the (re)phosphorylation of the channel after the calcineurin-dependent activation."
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