IndraLab

Statements

CLASP1 binds USP28. 11 / 11
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"The interaction between USP28 and MAST1 was observed using a Duolink in situ proximity ligation assay (PLA) kit (Cat."
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"The in situ USP28-MAST1 interaction was observed as red signals (PLA dots) when USP28 and MAST1 were immunostained together, but not when they were stained with individual antibodies (Fig.  xref C)."
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"On the basis of the above observations, we hypothesized that the interaction between USP28 and MAST1 might influence on MAST1 protein turnover."
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"We further used Duolink PLA assays to validate the interaction between USP28 and MAST1 under physiological conditions."
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"To delineate the molecular mechanism by which USP28 regulates MAST1 protein, we first examined the interaction between USP28 and MAST1 under physiological conditions."
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"On the basis of the above observations, we hypothesized that the interaction between USP28 and MAST1 might influence on MAST1 protein turnover."
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"The high mRNA expression score of USP28 was proportional with MAST1 expression (Fig.  xref C; Supplementary Table S5) and showed a positive correlation between USP28-MAST1 exhibiting r value of 0.36 (Fig.  xref D)."
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"We envision that targeting the USP28-MAST1 axis along with cisplatin treatment might be an alternative therapeutic strategy to overcome cisplatin resistance in cancer patients."
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"To delineate the molecular mechanism by which USP28 regulates MAST1 protein, we first examined the interaction between USP28 and MAST1 under physiological conditions."
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"These findings confirm that USP28 interacts with MAST1 protein at both endogenous and exogenous levels."
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"We further used Duolink PLA assays to validate the interaction between USP28 and MAST1 under physiological conditions."
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