IndraLab

Statements


USP7 increases the amount of KDM6B. 6 / 6
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"As expected, co-expression of USP7 increased the JMJD3 levels but decreased ubiquitinated JMJD3 levels (XREF_FIG D)."

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"It confirms that inhibition of USP7 through overexpression of miR-15b further suppressed the expression of KDM6B and inhibited the proliferation, differentiation, and autophagy of OBs, hereby exacerbating OP."

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"XREF_BIBR Similarly, our further mechanistic investigations demonstrated that overexpression of USP7 increased the protein level of JMJD3 and its ubiquitin modification level."

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"37, 38 In addition, a recent study has confirmed that USP7 could promote KDM6B expression by enhancing KDM6B stability."

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"USP7 promotes the expression of KDM6B by enhancing its stability."

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"USP7, importantly, strengthened the stability of KDM6B and promoted KDM6B expression."