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USP28 inhibits DNA Damage. 3 / 3
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"Likewise, Annexin-V-positive cells were increased in USP28-KO clones compared with USP28-depleted cells reconstituted with USP28 or MAST1 (Fig. 5G), indicating that loss of USP28 sensitizes cells to cisplatin-mediated DNA damage and induced cell death.Finally, we wished to investigate the molecular mechanism of USP28 regulation on MAST1-driven cisplatin-resistance."
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"Western blot analysis of γH2AX came to the same conclusions, showing that inhibition of USP28 induces DNA damage (Fig. 7F, I), while overexpression of USP28 led to an alleviated DNA damage upon olaparib treatment (Fig. 7G)."
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"The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage."
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