IndraLab

Statements

MINK1 activates KCNH2. 5 / 6
1 | 5
reach
"MiRP1 encoded by KCNE2 is thought to regulate KCNH2 in the human heart; MinK encoded by KCNE1 may also modulate KCNH2 in vivo; 14-3-3epsilon binding to KCNH2 channels shifts the activation curve towar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20950623
reach
"In addition, D76N and D85N KCNE1 (Mink) mutations also increased the in vitro sensitivity of IKr and hERG to inhibition by clarithromycin [XREF_BIBR]."
26926294
reach
"These studies indicate that, as in KVLQT1, mutations in minK can cause both autosomal dominant (Romano-Ward syndrome) and autosomal-recessive (JLN) LQT.Identification of SCN5A, HERG, KVLQT1 and minK a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9791861
reach
"MinK increases hERG currents by an unknown mechanism."
16050264
reach
"Although MinK most likely functions as the accessory subunit for KCNQ1 to form I Ks channels in the heart [XREF_BIBR, XREF_BIBR], MinK can also modulate hERG1 channel density when overexpressed in heterologous expression systems [XREF_BIBR, XREF_BIBR]."
20544339