IndraLab

Statements

MINK1 activates KCNH2. 6 / 6
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reach
"Although MinK most likely functions as the accessory subunit for KCNQ1 to form I Ks channels in the heart [XREF_BIBR, XREF_BIBR], MinK can also modulate hERG1 channel density when overexpressed in heterologous expression systems [XREF_BIBR, XREF_BIBR]."
20544339
reach
"MinK increases hERG currents by an unknown mechanism."
16050264
reach
"In addition, D76N and D85N KCNE1 (Mink) mutations also increased the in vitro sensitivity of IKr and hERG to inhibition by clarithromycin [XREF_BIBR]."
26926294
signor
"Herg, a human homologue of the ether-a-go-go gene of the fruitfly drosophila melanogaster, encodes aproteinthat produces the rapidly activating cardiac delayed rectifier (i[kr]). / our results show that mink physically associates with herg and that the interaction leads to increased ikr current density."
9230439
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"MiRP1 encoded by KCNE2 is thought to regulate KCNH2 in the human heart; MinK encoded by KCNE1 may also modulate KCNH2 in vivo; 14-3-3epsilon binding to KCNH2 channels shifts the activation curve towar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20950623
reach
"These studies indicate that, as in KVLQT1, mutations in minK can cause both autosomal dominant (Romano-Ward syndrome) and autosomal-recessive (JLN) LQT.Identification of SCN5A, HERG, KVLQT1 and minK a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9791861