IndraLab

Statements

Diosmetin inhibits NLRP3. 4 / 4
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"Rosuvastatin and diosmetin inhibited the HSP70/TLR4 /NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin."
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"Further supporting these results, in vitro experiments also showed that diosmetin activated Nrf2 and HO-1, as well as inhibited the NLRP3 inflammasome in both RAW264.7 and A549 cells."
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"While further studies are required to acquire more insight into the mechanisms underlying how diosmetin leads to Nrf2 activation and NLRP3 inhibition, as well as the relationship between these two pathways."
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"Diosmetin inhibits the NLRP3 inflammasome pathway and inflammatory cytokines IL-1β and IL-18 in PC12 cells in OGD/R conditions [110]."
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