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USP35 inhibits intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. 4 / 4
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"Moreover, the expression of USP35 is positively correlated with poor prognosis of non-small cell lung cancer (NSCLC) and represses endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 [36]."
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"USP35 stabilizes ribosome binding protein 1 (RRBP1) and reduces endoplasmic reticulum stress-induced apoptosis in NSCL [190]."
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"For example, USP35 can reduce the endoplasmic reticulum stress-induced apoptosis by stabilizing ribosomal binding protein 1 (RRBP1) (Garcia-Santisteban et al., 2013; Wang et al., 2022)."
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"Furthermore, USP35 attenuates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer cells (25)."
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