IndraLab

Statements

TNFAIP3 inhibits Arthritis. 4 / 4
| 3 1
eidos
"Additionally , domain-specific mutant mice can be generated by mutating OTU ( C103A ) , ZnF4 ( C609A and C612A ) , or ZnF7 ( C764A and C767A ) and other specific sites The inflammatory features of arthritis and the anti-inflammatory function of A20 suggest that A20 can suppress arthritis by restricting inflammation , which has been verified by a growing number of studies ."
| PMC
eidos
"More recently , it has been shown that A20 restricts Th17 cell expansion and arthritis through its ZnF7 motif [ 28 ] ."
| PMC
eidos
"A20 prevents arthritis by inhibiting macrophage necroptosis and restricting spontaneous immune activation through its ZnF7 Necroptosis is a modified form of necrosis in which dead cells break up and release intracellular components , triggering an innate immune response that includes IL-1beta release and NLRP3 inflammasome activation [ 29 , 57 ] ."
| PMC
reach
"Spontaneous arthritis induced by myeloid-specific deletion of the RA susceptibility gene Tnfaip3 requires inflammasome signaling, as a deficiency in either Nlrp3, casp1/11, or Il1r1 genes in this model rescued arthritic phenotypes [73]."
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