IndraLab

Statements

TNFAIP3 inhibits Arthritis. 3 / 3
| 3
eidos
"Additionally , domain-specific mutant mice can be generated by mutating OTU ( C103A ) , ZnF4 ( C609A and C612A ) , or ZnF7 ( C764A and C767A ) and other specific sites The inflammatory features of arthritis and the anti-inflammatory function of A20 suggest that A20 can suppress arthritis by restricting inflammation , which has been verified by a growing number of studies ."
| PMC
eidos
"A20 prevents arthritis by inhibiting macrophage necroptosis and restricting spontaneous immune activation through its ZnF7 Necroptosis is a modified form of necrosis in which dead cells break up and release intracellular components , triggering an innate immune response that includes IL-1beta release and NLRP3 inflammasome activation [ 29 , 57 ] ."
| PMC
eidos
"More recently , it has been shown that A20 restricts Th17 cell expansion and arthritis through its ZnF7 motif [ 28 ] ."
| PMC