IndraLab

"We found several previously poorly characterized monocyte/macrophage ligand-receptor interactions with lung epithelial cells and other myeloid cells, most apparent at D3, that may be involved in driving later-stage damage and regulating phagocytosis (e.g. TGFB1-ITGB6 and ITGB8, SPP1-ITGAV, SIRP1a-CD47; Fig. 4E )."

"We examined lung epithelial cell receptor interactions with severity-associated ligands ( Figure 6D) ; a correlation matrix of plasma ligand abundance identified coregulated groups of proteins that act on lung epithelial cells, including protein modules for regeneration and growth factor signaling (module 1: growth factors EGF, TGFB1, and VEGFA, and anti-apoptotic factor DKK1; module 2: growth factors BMP6 and HGF, and Wnt signaling pathway activators RSPO3 and RSPO1) and for IL6 pathway other myeloid cells, most apparent at D3, may drive later-stage damage, immune suppression, and regulation of phagocytosis (e.g., ligand-receptor interactions TGFB1-ITGB6 and -ITGB8, SPP1-ITGAV, SIRPA-CD47; Figure 6E )."

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"In this process, latent TGFβ1 could bind to ITGB6 and become activated to stimulate the Smad3 pathway."