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BAP1 binds ERK. 3 / 3
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sparser
"Further examination revealed that BAP1 interacts with phosphorylated ERK1/2, deubiquitinating their ubiquitins, and thus attenuating the ERK signaling pathway."
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sparser
"Collectively, these results suggest that the binding of BAP1 to phosphorylated-ERK1/2 may lead to a reduction in its phosphorylation."
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reach
"Surprisingly, we found that neither ERK1/2 nor any other signaling molecules upstream of ERK bound to BAP1; only phosphorylated-ERK1/2 co-precipitated with endogenous BAP1 (Fig. 4B)."
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