IndraLab

Statements

USP7 activates RELA. 3 / 3
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"A study reported that USP7 is critical for target gene transcription, whereby USP7 targeted NF-kappaB p65 for K48 linked deubiquitination, increased the protein stability of p65, and ultimately led to increased transcription."
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"Altogether, our findings highlighted that USP7 promoted the occurrence of LN by regulating the NF-kappaB p65 signaling pathway via stabilization of JMJD3."
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"USP7 removes polyubiquitin chains from p65 and promotes transcription by increasing the stability and half-life of transcriptionally active p65 [36]."
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