IndraLab

Statements

AKAP5 binds KCND2. 5 / 5
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"Disruption of PKA anchoring to AKAP79 by applying a stearated, membrane-permeant peptide, Ht31, which resembles the AKAP79 binding site for PKA ( xref ), also did not affect AKAP79-Kv4.2 co-IP ( xref ), suggesting that PKA subunits are not required for AKAP79-Kv4.2 interaction."
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"Corresponding effects on neuronal excitability show the Kv4.2-AKAP79 interaction is physiologically important, providing a mechanism for rapid, dynamic regulation of intrinsic neuronal excitability of hippocampal neurons."
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"The sum of our co-IP experiments indicates a direct interaction between Kv4.2 and AKAP79."
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"These data show that phosphorylation at this site was not necessary for AKAP79-Kv4.2 interaction."
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"Subsequent co-IP experiments suggested, however, that Kv4.2-AKAP79 binding does not require MAGUK intermediate proteins as the two proteins were still found in complex after deleting the PDZ domain of Kv4.2 ( xref ) which is necessary for PSD-95 interaction with Kv4.2 ( xref )."
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