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COPS6 activates Neoplasm Invasiveness. 24 / 24
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"As shown in Fig. 3 , overexpression of FOXA1 could enhance CFPAC-1 cells’ invasion and metastasis abilities, and the re-expression of FOXA1 could attenuate the decrease of invasion and metastasis indu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Also, WT CSN6 increased cell migration and invasion in a wound healing assay (p < 0.001, XREF_FIG) and in transwell migration and invasion assays (XREF_FIG), whereas CSN6 S148A lost such capability, demonstrating that the CSN6 promoted migration and invasion of colon cancer cells requires a phosphorylation event."
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"Our results showed that knocking down FOXA1 inhibited the increase of invasion and metastasis abilities stimulated by overexpression of CSN6 ( Fig. 3 g-j)."
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"In summary , these findings demonstrated that downregulation of CSN6 expression could inhibit cell proliferation , migration and invasion ."
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"CSN6 promotes GBM proliferation , migration , invasion , and tumorigenesis through upregulation of EGFR by blocking its ubiquitination ; this happens as a result of interactions with CHIP that cause its degradation , although CHIP auto-ubiquitination occurs through an unknown mechanism [ 91 ] ."
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"Here , we identified that CSN6 promoted melanoma cell migration and invasion in vivo ."
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"CSN6 promotes the migration and invasion of CC cells through inhibiting autophagy."
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"Both COPS6 and COPS9 overexpression promoted HCC cell migration and Matrigel invasion in transwell assays, while COPS6 siRNA transfection or COPS9 siRNA transfection repressed transwell migration and Matrigel invasion (Figure 11C)."
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"Furthermore, migration and invasion assays showed that knockdown of CSN6 reduced cell migration and invasion in DLD-1."
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"Overexpression of COPS6 or COPS9 increased HCC cell proliferation, migration, and invasion while knockdown suppressed these pro-tumorigenic and metastatic properties."
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"In this study, we show that CSN6 promotes the growth, migration and invasion of melanoma cells via CDK9 mediated signaling pathways."
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"CSN6 recovery rescued the cell proliferation, migration, and invasion of CSN6-knockdown melanoma cells."
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"Overexpression of CSN6 promoted processes of HCC cell proliferation, migration, and invasion, while these processes were inhibited when CSN6 was silenced."
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"CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L. CSN6 is one subunit of the highly conserved constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is overexpressed in many types of cancers, and has received great attention as a regulator of the degradation of cancer-related proteins, suggesting its importance in oncogenic activity."
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"Here, we identified that CSN6 promoted melanoma cell migration and invasion in vivo."
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"Taken together, we concluded that CSN6 might promote the migration and invasion of cervical cancer cells by inhibiting autophagic degradation of CTSL and serve as a potential gene therapy target for the treatment of CC metastasis."
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"These results suggest that CSN6 robustly modulates PTC migration and invasiveness."
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"CSN6 promotes CC cells migration and invasion."
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"In melanoma cells , CSN6 knockdown remarkably inhibited cell proliferation , tumorigenicity , migration , and invasion , whereas CSN6 recovery rescued the proliferative and metastatic abilities ."
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"Results showed that COPS6 knockdown suppressed the promotion of proliferation, invasion, and migration of CRC cells induced by overexpressed ALDOA (Figures 8(a)–8(g))."
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"In vitro and in vivo data showed that loss of CSN6 attenuated cell proliferation, migration, and invasion of PTC cells, confirming the vital function of CSN6 in PTC."
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"Here, we report that GBM tumors overexpressed CSN6 compared with normal brain tissues and that CSN6 promoted GBM cell proliferation, migration, invasion and tumorigenesis."
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"As showed in our results, inhibiting expression of CSN6 repressed the migration and invasion abilities of CFPAC-1 cells in vitro( Fig. 2 c and d)."
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"Overexpression of CSN6 increased the migration and invasion abilities of PANC-1 cells in vitro ( Fig. 2 j and k) and the metastasis of liver in vivo ( Fig. 2 l and n)."
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