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7-(3,5-dimethyl-4-isoxazolyl)-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-3H-imidazo[4,5-c]quinolin-2-one inhibits IFNB1. 2 / 2
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"We next addressed whether, in addition to inhibiting IFN-beta production, I-BET151 could also inhibit IFN-beta function by suppressing cellular responses to IFN-beta."
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"Similar to the TLR3-TBK1-IRF3 pathway, we found that BI-2536, JQ1 and I-BET151 blocked the TLR7- or TLR9 stimulated secretion of IFNbeta in Gen2.2 cells (XREF_FIG A and XREF_FIG B), without affecting the TLR stimulated translocation of the endogenous IRF5 to the nucleus (XREF_FIG C)."
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