IndraLab

Statements

USP50 binds STS. 2 / 2
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"Taken together, these data suggested that USP50 physically interacted with and deubiquitinated ASC to induce ASC speck formation and oligomerization.3.5 USP50 stimulates HMGB1 release in DGR-induced gastric inflammation."
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"Therefore, these results show that the binding of USP50 with ASC protein to deubiquitinate K63 linked polyubiquitination is a crucial step for inflammasome activation."
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