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USP12 activates EP300. 4 / 4
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"According to a recent study, USP12 (ubiquitin-specific protease 12) via enhancing p300/MTLL3 axis promote myocardial hypertrophy [61], and our finding may indicate the possibility of m A methylation and ubiquitination cooperatively regulate heart growth."
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"These data indicated that USP12 blocked p300 degradation and stabilized p300 protein.Many studies have demonstrated that USP12 plays a role in stabilizing protein by binding to the substrate and inhib[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further, we demonstrated that USP12 positively regulated p300, a methyltransferase which could promote H3K27 acetylation in the promoter of METTL3 and induce METTL3 transcription [ 24 ]."
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"First, USP12 can prolong the half-life of p300 protein."
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