IndraLab

Statements

USP4 increases the amount of TWIST1. 3 / 3
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"Li et al. revealed that USP4 promoted lung cancer cell stemness by stabilizing Twist1 protein expression [22]."
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"These results indicate that FBXO3 increases Twist1 and USP4 protein expression in an E3 ligase activity-independent manner, in which the FBXO3-ApaG domain is indispensable.To investigate the causal effects of USP4 on FBXO3-induced Twist1 expression and cell migration, we performed rescuing experiments."
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"The current study provides evidence that USP4 increases the protein levels of Twist1 and β-catenin, subsequently promoting stemness and drug resistance in CRC."
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