IndraLab

Statements

UL12 binds USP15. 4 / 4
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sparser
"We demonstrate that USP15 directly interacts with UL12 and that in the absence of USP15, less UL12 is observed."
40824090
sparser
"We propose that UL12 binds USP15 and recruits it to the nucleus, where it becomes phosphorylated and then subsequently facilitates viral DNA replication and recombination."
40824090
sparser
"This study, however, does not exclude the possibility that the UL12-USP15 interaction modulates other aspects of the DNA damage response to cause the increase in homology-directed repair."
40824090
sparser
"We demonstrated that UL12 interacts directly with USP15, and that UL12 is necessary and sufficient for USP15 localization to the nucleus and sites of DNA replication during infection."
40824090