IndraLab

Statements

USP18 inhibits NF-κB.. 2 / 2
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reach
"Our genome wide analyses reveal that nuclear USP18 diminishes binding of IFN-regulated transcription factors to their corresponding DNA motifs in cooperation with NF-κB."
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reach
"We identified that nuclear USP18 diminishes binding of IFN regulated transcription factors to their corresponding DNA motifs in cooperation with NF-κB. Consequently, the suppression of USP18 not only enhances the expression of canonical IFN-stimulated genes (ISGs) but also activates a set of atypical ISGs and NF-κB target genes that induce cancer pyroptosis."
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