IndraLab

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USP7 increases the amount of AKT. 2 / 2
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"However, our results show that USP7 knockdown decreases the expression levels of MDM2, AKT, and NF-kappaB genes without being dependent on p53 protein."
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"All these results confirmed that USP27X‐AS1 recruited USP7 to bind AKT.Furthermore, decreasing USP7 expression using siRNAs downregulated AKT protein expression (Figure 5J and Figure S6I), while overexpression of USP7 increased AKT protein expression (Figure 5K)."
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