IndraLab

Statements

USP4 is phosphorylated on S65. 3 / 3
| 3
rlimsp
"The cleavage of K48-linked dimers of Ub by OTU family DUBs (OTUB1 and OTUB2) and several USP family DUBs (USP4, USP16, USP21, and VCPIP1) was activated by phosphorylation of Ser65, but it was deactivated by phosphorylation at Ser20 or Ser57 (Figures 5F and 6G)."
27425610
rlimsp
"Ser65 phosphorylation increased USP4-mediated cleavage of K11- and K48-linked Ub, but it decreased USP4-mediated cleavage of K6-, K29-, and K33-linked Ub (Figure 6O)."
27425610
rlimsp
"The cleavage of K48-linked dimers of Ub by OTU family DUBs (OTUB1 and OTUB2) and several USP family DUBs (USP4, USP16, USP21, and VCPIP1) was activated by phosphorylation of Ser65, but it was deactivated by phosphorylation at Ser20 or Ser57 (Figures 5F and 6G). The cleavage of K63-linked Ub by USP8 and USP36 was severely attenuated by phosphorylation of Ser65 in Ub, but phosphorylation at Ser20 or Ser57 had little effect on cleavage of K63-linked Ub by these enzymes (Figures 5G and 6H)."
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