IndraLab

Statements

USP10 inhibits AKT. 12 / 12
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"To our attention, USP10 was also found to suppress the AKT/mTOR signaling pathway by inhibiting PTEN, but the underlying mechanisms are controversial."
34416231
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"Another study showed that USP10 inhibits the AKT/mTOR signaling but does not provide sufficient data on PTEN stability in hepatocellular carcinoma cells (33)."
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"In the present study, we screened a panel of Dubs to identify novel modulators on PTEN/AKT/mTOR signaling and found that USP10 suppresses AKT activation."
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"In agreement with this finding, depletion of USP10 by sgRNA triggered the activation of AKT/mTOR signaling (Fig. 5E)."
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"In addition, USP10 inhibited the activation of AKT/mTOR signaling (Lu et al. 2018)."
40278953
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"USP10 suppresses ABCG2-induced malignant characteristics of doxorubicin-resistant thyroid cancer by inhibiting PI3K/AKT pathway."
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"USP10 is lowly expressed in NSCLC cells and suppresses the activation of the AKT/mTOR signaling pathway."
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"USP10 was reported to inhibit tumor growth and inactivate mTORC1 and AKT signaling by stabilizing AMPKalpha and PTEN in HCC cells."
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"Mechanistic studies demonstrated that USP10 suppresses the activation of the AKT/mTOR pathway via decreasing the K63-linked polyubiquitination of PTEN, which resulted in the inhibition of the cell viability, proliferation, and migration of the A549 and H1299 NSCLC cell lines."
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"The activation of the AKT/mTOR pathway was confirmed in TGF-β1-induced HLF, and USP10 overexpression inhibited AKT/mTOR activation (Fig. S1F, G)."
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"These data thus demonstrated that USP10 might activate PTEN, thus inhibiting the AKT/mTOR signaling pathway."
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"Mechanistically, overexpressing USP10 inhibited PI3K/AKT pathway by activating PTEN."
37919637