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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP10 inhibits AKT. 2 / 2

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"USP10 was reported to inhibit tumor growth and inactivate mTORC1 and AKT signaling by stabilizing AMPKalpha and PTEN in HCC cells."

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"Specifically, USP10 activates PTEN by preventing its K63 linked polyubiquitination mediated by TRIM25 and suppresses the AKT and mTOR signaling pathway thereby inhibiting NSCLC proliferation, indicating that it may be a potential drug target for cancer treatment."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...