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NKD1 decreases the amount of USP15. 3 / 3
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"4 , 33 Regarding the mechanism of NKD1 promoting the ubiquitination and degradation of APC, we found that NKD1 promoted the ubiquitination and degradation of APC by inhibiting the expression of deubiquitination enzyme USP15 and blocking the interaction between SUP15 and APC."
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"Furthermore, Western blot demonstrated that overexpression of NKD1 in colon cancer HCT116 cells significantly reduced the expression of USP15, while knockdown of NKD1 in RKO cells evidently increased USP15 expression (Figure 9C), which implied that NKD1 prohibited the expression of USP15 in colon cancer cells."
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"Altogether, these results present that NKD1 not only represses the expression of the USP15 protein but also blocks the binding between USP15 and APC.3.10 NKD1 promoted colon cancer cell proliferation and migration by inhibiting APC ."
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